In a study of an immune therapy for colorectal cancer that involved a single patient, a team of researchers at the National Cancer Institute (NCI) identified a method for targeting the cancer-causing protein produced by a mutant form of the KRAS gene. This targeted immunotherapy led to cancer regression in the patient in the study. The finding appeared Dec. 8, 2016, in the New England Journal of Medicine. The study was led by Steven A. Rosenberg, M.D., Ph.D., chief of the Surgery Branch at NCI’s Center for Cancer Research, and was conducted at the NIH Clinical Center. NCI is part of the National Institutes of Health (NIH).
More than 30 percent of all human cancers are driven by mutations in a family of genes known collectively as RAS, which has three members: KRAS, NRAS, and HRAS. Mutations in the KRAS gene are thought to drive 95 percent of all pancreatic cancers and 45 percent of all colorectal cancers. A mutation called G12D is the most common KRAS mutation and is estimated to occur in more than 50,000 new cases of cancer in the United States each year. Because of their importance in cancer causation, worldwide efforts to successfully target mutant RAS genes are being pursued. Such efforts have met with limited success to date.
In attempting to develop more effective approaches to targeting RAS, Rosenberg’s team isolated tumor infiltrating lymphocytes (TILs) that targeted the KRAS G12D mutation from tumor nodules in the patient’s lungs that developed after colorectal cancer cells had spread to the lungs. TILs are white blood cells that migrate from the bloodstream into a tumor. Continue reading
Celegene is making progress in its treatment for Ulcerative Colitis by its drug Ozanimod, which is under Phase 2 Clinical Trials currently.
About Ulcerative Colitis: Ulcerative colitis is a chronic, relapsing condition triggered by an abnormal, prolonged immune response that creates long-lasting inflammation and ulcers (sores) in the mucosa (lining) of the large intestine (colon). Symptoms usually develop over time, rather than suddenly. The disease can be debilitating and can sometimes lead to life-threatening complications. Ulcerative colitis is the most common form of inflammatory bowel disease worldwide. About one in every 198 people in Europe, and one in every 402 people in North America, have ulcerative colitis. In 2004, 2.1 million prescriptions were written to treat ulcerative colitis, and 716,000 ambulatory care visits were related to the disease. In 2010, there were 107,000 hospitalizations due to ulcerative colitis.
Following is a press release by the company dated 18 march 2016. Continue reading
Posted in Digestive System, Health Innovations, Health Research, Immune System
Tagged Celgene, colon ulcers, Dr. William Sandborn, Gastroenterology, inflammatory bowel disease, Touchstone, Ulcerative Colitis, ulcers, University of California San Diego
Hemorrhoids are swollen areas of skin and blood vessels around the anus, which usually develop around the external opening of the anus, but can be internal too. They are caused by high pressure on the anal region and due to over exerting during a bowel movement. They are highly innervated and sensitive and are also at risk for thrombosis. They develop around the external opening of the anus. Internal hemorrhoids occur above the pectinate or dentate line in the anal canal.
The internal hemorrhoid is graded to assist with the selection of a treatment plan. The treatment is then provided according to the grade. The grade of the hemorrhoid depends on the extent of descent into the anal canal and out of the anus. Continue reading
Gastroesophageal reflux, also known as acid reflux, can be a serious health hazard. Acid reflux is a chronic condition in which hydrochloric (stomach) acid escapes through the lower esophageal sphincter (LES) and enters the esophagus. Acid Reflux Symptoms include: heartburn, burping, ongoing hiccups, chronic sore throat, abdominal pain, regurgitation.
More About Acid Reflux: While it’s not uncommon to experience these symptoms sporadically, if they occur twice a week or more you have acid reflux disease. Risk factors include being overweight, pregnancy, eating large meals or lying down after a meal. Acid reflux can also be caused by lack of digestive enzymes. And for that, Digestive Science Reflux Elimination System is ideal because it is a safe and natural therapy to treat a common cause of acid reflux and reduce the pain that it causes. And similarly, just as acid reflux may signify that all’s not well with the state of your body, Reflux Elimination System may be a wise investment for your health and your comfort. Continue reading